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The most up-to-date version of our website is at:

www.GenomeDataLab.org
GenomeDataLab @ IRB
  • // home
  • / research interests
    • [1] DNA repair genomics
    • [2] mRNA quality control
    • [3] cancer evolution
    • [4] gene function inference
  • / the team
  • / projects
    • ERC HYPER-INSIGHT
    • H2020 DECIDER
    • MICINN REPAIRSCAPE
  • / our publications
    • [1] DNA repair genomics
    • [2] mRNA quality control
    • [3] cancer evolution
    • [4] gene function inference
  • / software
  • / join us
GenomeDataLab @ IRB
  • // home
  • / research interests
    • [1] DNA repair genomics
    • [2] mRNA quality control
    • [3] cancer evolution
    • [4] gene function inference
  • / the team
  • / projects
    • ERC HYPER-INSIGHT
    • H2020 DECIDER
    • MICINN REPAIRSCAPE
  • / our publications
    • [1] DNA repair genomics
    • [2] mRNA quality control
    • [3] cancer evolution
    • [4] gene function inference
  • / software
  • / join us
  • More
    • // home
    • / research interests
      • [1] DNA repair genomics
      • [2] mRNA quality control
      • [3] cancer evolution
      • [4] gene function inference
    • / the team
    • / projects
      • ERC HYPER-INSIGHT
      • H2020 DECIDER
      • MICINN REPAIRSCAPE
    • / our publications
      • [1] DNA repair genomics
      • [2] mRNA quality control
      • [3] cancer evolution
      • [4] gene function inference
    • / software
    • / join us

Genome Data Science

laboratory


// BIST / Institute for Research in Biomedicine (IRB Barcelona) / Cancer Science programme / @GenomeDataLab

[1] genomics of DNA repair failures
[2] transcriptome quality control
[3] predicting cancer evolution
[4] automated gene function inference

In the GenomeDataLab, we use statistical genome analyses and machine learning methodologies for studies of massive genomic, epigenomic and transcriptomic data sets.

We aim to address outstanding questions in biology and biomedicine by insightful analysis of data originating from human tumors (somatic mutations, transcriptomes), human populations (germline variation) and metagenomes (incl. human microbiomes).

We study mechanisms of maintaining genome integrity in human cells via statistical analyses of mutation patterns in cancer. Next, we are interested in how mRNA synthesis and turnover pathways shape genomes and transcriptomes in health and disease. Finally, we combine experimental work and genomics to scan cancer genomes for driver genes and for genetic interactions to predict tumor evolution and identify novel synthetic lethalities.

read more about our research interests >>> [ 1 ] [ 2 ] [ 3 ] [ 4 ]

Some recent publications from the GenomeDataLab:

Mas-Ponte and Supek, Nature Genetics, 2020
Mas-Ponte & Supek (2020) Nature Genetics
Salvadores, Fuster and Supek, Science Advances, 2020
Salvadores, Fuster-Tormo & Supek (2020) Science Advances
Lindeboom, Vermeulen, Lehner and Supek, 2019, Nature Genetics
Lindeboom, Vermeulen, Lehner & Supek (2019) Nature Genetics

read more about our work on: [1] genomics of DNA repair failures; [2] transcriptome quality control; [3] predicting cancer evolution; and [4] automated gene function inference

Meet the GenomeDataLab team:

Fran
Fran Supekgroup leader
ICREA professor
EMBO YIP
Daniel
Marina Salvadores
Marina
David Mas-Ponte
David
Marcel McCollough
Marcel
Iván
Ignasi Toledano
Ignasi
Víctor
Miguel
Bruno
Guille
Tiffany Delhomme
Tiffany
Elizaveta Besedina
Liza



more info on
team members >>>


follow us on Twitter!
@genomeDataLab >>>

We gratefully acknowledge our funders:

European Research Council ERC Starting Grant #757700 HYPER-INSIGHT "Insight into genome maintenance and cancer vulnerabilities provided by an extreme burden of somatic mutations "


Fran Supek is an EMBO Young Investigator.

Lab funding and fellowships are funded by the Severo Ochoa excellence award to the IRB Barcelona.

PI is tenured by the ICREA Research Professor program.

We are further funded by the European Union Horizon2020 program (DECIDER), the Spanish government (REPAIRSCAPE), the Catalan science agency, and the Croatian Science foundation. More information on projects >>>

We are a part of the Institute for Research in Biomedicine (IRB Barcelona), a member of the Barcelona Institute of Science and Technology:

"Prediction is very difficult, especially about the future." -- Niels Bohr.

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